FREEPORT — An elderly man was killed Wednesday night when the car he was driving in the wrong lane struck a second car head-on on Route 295, according to Maine State Police investigating the crash.

Police said the victim was killed instantly. The car he hit was driven by a woman who was taken to Maine Medical Center in Portland with multiple injuries, police said. Those injuries were not believed to be life-threatening.

The crash took place just after 7 p.m. in the southbound lane, near the Mallet Drive exit. None of the victims was identified late Wednesday.

State police received a number of calls of a car going the wrong way in Freeport just prior to the crash and they are attempting to determine where the car got on Route 295. The names of both drivers will likely be released Thursday morning, Maine Public Safety spokesman Stephen McCausland said.

The southbound lane was closed for almost two hours, backing up traffic into Brunswick. One lane reopened at about 9 p.m.

A team of state police troopers was investigating, McCausland said.