BOSTON — Tanner Houck allowed three runs in six strong innings and Tyler O’Neill hit a three-run homer to help the Boston Red Sox defeat the Philadelphia Phillies 9-3 on Thursday night.

Jarren Duran doubled in his first two at-bats and also drove in two runs as the Red Sox secured a series win against the NL-leading Phillies. David Hamilton, Reese McGuire, Dominic Smith and Enmanuel Valdez also drove in runs for Boston.

Houck (7-5) scattered eight hits, struck out five and walked none. His ERA rose to 2.08.

Kyle Schwarber drove in all three of Philadelphia’s runs. Phillies starter Aaron Nola (8-3) delivered his worst outing since his first start of the season.

Valdez and McGuire jumped on consecutive pitches in the second inning for a pair of doubles that led to Boston scoring the game’s first run. Nola allowed five straight hits in the inning, four of them doubles. Duran’s second double of the game, which drove in two, was the fifth consecutive hit given up by Nola in the four-run second.

After allowing two hits and hitting a batter, Houck watched his 3-1 pitch to Schwarber turn into a bases-clearing double that pulled the Phillies to within one run in the fourth.

Boston regained some breathing room in the bottom of the fourth and chased Nola from the game. The righty was tagged for four more runs – three coming on O’Neill’s 12th home run – and was removed after allowing his most runs in a start this season.

Nola gave up eight runs and 11 hits in 3 2/3 innings. His ERA jumped from 2.77 to 3.48.

Brad Keller pitched three innings in relief for Boston to earn his first save of the season.

TRAINER’S ROOM

Phillies: Outfielder Brandon Marsh (right hamstring strain) began what could amount to a two-game rehab assignment with Double-A Reading on Thursday night. Marsh served as Reading’s DH and went 3 for 5 against the Portland Sea Dogs. Before Thursday’s game in Boston, Manager Rob Thomson said Marsh is slated to see time in center field on Friday night for the Fightin Phils. Thomson said Marsh “possibly” could be activated from the IL on Saturday. “We’ll see how it goes,” Thomson added. … Shortstop Trea Turner (left hamstring strain) ran the bases “really good” Thomson said. Turner is scheduled to run the bases again Friday. Thomson ruled out a rehab assignment for the shortstop.

Red Sox: First baseman Triston Casas (rib) took grounders on the field during batting practice. He has yet to be cleared to take swings. The Red Sox hope he can come off the 60-day IL in early July. … Utilityman Romy Gonzalez, on the IL since May 31 because of a strained left hamstring, went 1 for 2 with a walk in a rehab game for Triple-A Worcester on Thursday night.