LONDON — Marketa Vondrousova became the first defending women’s champion at Wimbledon to lose in the first round the next year since 1994, eliminated 6-4, 6-2 by Jessica Bouzas Maneiro at Centre Court on Tuesday.

Vondrousova was a surprise title winner at the All England Club 12 months ago, the first unseeded woman to claim the trophy at the grass-court Grand Slam tournament.

Now she enters the books in another – and less-wanted – historic way. The only other time in the sport’s Open era, which dates to 1968, that a woman went from a championship at Wimbledon to an immediate exit a year later was when Steffi Graf was defeated by Lori McNeil 30 years ago.

“I was happy to be back on the Centre Court,” Vondrousova said. “It just didn’t go as planned today.”

Vondrousova was seeded No. 6 this time, but the left-hander, who was the runner-up at the 2019 French Open and a silver medalist at the Tokyo Olympics three years ago, was never quite able to demonstrate her full game Tuesday. She appeared to still be suffering after-effects from a fall during a tuneup tournament on grass in Berlin last month that hurt her hip.

“I was a bit slower, maybe. I was a bit scared,” Vondrousova said. “But credit to her. She was playing a good match, too. I didn’t feel at my best, (but) she didn’t gave me many points for free.”

How big a deal was this for Bouzas Maneiro?

She is competing in a Grand Slam tournament for only the third time and came into the day with an 0-2 record at those events. Bouzas Maneiro also had never won a match at a tour-level grass tournament and never beaten an opponent ranked in the top 10.

“This is one of the most important moments in my life, in my career, here in this sport. This is amazing,” said Bouzas Maneiro, a 21-year-old from Spain who is ranked 83rd this week, equaling her career high.

“I was like, ‘I have no pressure. Just enjoy the moment, enjoy the tournament.’ Just trying to be free playing, and I did it, so I’m happy for that,” she said.

Vondrousova added to the series of past major title winners dropping out of the singles brackets within the first 30 hours of action at Wimbledon this year – although others did so without playing a point.

Two seeded women who both have been ranked No. 1 and own two Australian Open championships apiece, No. 3 Aryna Sabalenka and No. 16 Victoria Azarenka, withdrew on Monday before their first-round matches because of shoulder injuries. Sabalenka was the pretournament favorite to take the women’s title, according to BetMGM Sportsbook.

Intermittent rain delayed matches on the outside courts more than once Tuesday, and the retractable roofs at Centre Court and No. 1 Court were shut to allow play in those two stadiums. Early winners included 2022 champion Elena Rybakina and No. 5 seed Jessica Pegula among the women, and No. 7 Hubert Hurkacz among the men.

The initial signs of trouble for Vondrousova on Tuesday came right away: She double-faulted three times in the very first game and got broken to trail 1-0.

“My serve wasn’t so good today,” Vondrousova said. “Overall, I think, I wasn’t at my best.”

She wound up with seven double-faults, part of her total of 28 unforced errors, twice as many as Bouzas Maneiro in a match that lasted only a little more than an hour.

“I’m surprised with myself, honestly. At the beginning, I was a little bit nervous, but then … the atmosphere was so nice,” Bouzas Maneiro said. “I was comfortable here playing, and I was like at home. I don’t know why.”

NOVAK DJOKOVIC, playing his first match since tearing the meniscus in his knee at the French Open on June 3 and having surgery, never faced a break point along the way to a 6-1, 6-2, 6-2 victory over qualifier Vit Kopriva in under two hours on Centre Court.

“Very pleased with the way I felt on the court. Obviously, coming into Wimbledon this year was little bit of different circumstances for me, because of the knee. I didn’t know how everything was going to unfold on the court, really,” Djokovic said. “Practice sessions are quite different from official match play. I’m just extremely glad (with) the way I felt today, the way I played.”

He accumulated 15 break chances, converting six, and delivered his usual clean strokes, finishing with twice as many winners, 32, as unforced errors, 16.

There were plenty of quick points, which probably was at least in part a result of Djokovic trying not to spend too much time running more than he needed to. He ended up taking 68 of the 91 exchanges that lasted four or fewer strokes.

“I tried to really focus on the game and not really think too much about the knee,” Djokovic said. “Everything I could possibly do, I’ve done, along with my team, in the last 31/2 weeks in order to give myself a chance to be able to play.”

The 37-year-old Djokovic has won seven of his men’s-record 24 Grand Slam titles at the All England Club and was the runner-up to Carlos Alcaraz last year.

ANDY MURRAY withdrew from singles at Wimbledon a little more than a week after surgery to remove a cyst from his spine, and the two-time men’s champion at the All England Club said he would make his farewell appearance at the tournament by playing doubles with his older brother, Jamie.

“I’m disappointed. I wanted to play in the tournament, and I wanted to have a chance to go out there and walk out on my own on Centre Court again and give it another go. But I also was only going to do that if I felt like I could be competitive. And I didn’t feel like that today,” Murray said.

The 37-year-old Murray – who has been planning to retire after the Paris Olympics, which start later this month – was supposed to face Tomas Machac at Centre Court on Tuesday in the first round of singles. Murray was replaced in the bracket by David Goffin, who lost during qualifying rounds last week.