CLEVELAND — Rookie Jake Moody missed a 41-yard field goal with six seconds left, leaving San Francisco stunned 19-17 by the Cleveland Browns, who ended the 49ers’ regular-season winning streak at 15 on Sunday and handed quarterback Brock Purdy his first loss as an NFL starter.

Dustin Hopkins kicked four field goals for the Browns (3-2) – the last with 1:40 left, capping a drive helped by a disputed unnecessary roughness call against San Francisco (5-1). Cleveland pulled off the league’s biggest upset this season without quarterback Deshaun Watson, who missed his second straight game with a bruised right shoulder.

The 49ers were short-handed without playmakers Christian McCaffrey and Deebo Samuel, who both went out with injuries. McCaffrey couldn’t push through an injury to his oblique in the second half. Samuel injured his shoulder in the first half and didn’t return.

P.J. Walker came off Cleveland’s practice squad and outplayed Purdy, who threw his first interception this season and finished with just 125 yards.

The 23-year-old Purdy had won his first 10 starts and nearly pulled out a comeback. He drove the 49ers into field-goal range in the final seconds before Moody pushed his attempt to the right. When the ball sailed into the net, Cleveland’s sideline erupted in celebration and Browns fans danced in the aisles.

JETS 20, EAGLES 14: Breece Hall ran for an 8-yard touchdown with 1:46 remaining, one play after Tony Adams intercepted Jalen Hurts, and New York held on to shock previously undefeated Philadelphia at East Rutherford, New Jersey.

The Jets (3-3) appeared on their way to falling to 0-13 in their history against the Eagles, but Hurts’ third interception of the game – and the fourth turnover by Philadelphia – was returned by Adams 45 yards to put New York into immediate scoring position.

Hall’s run shook MetLife Stadium as the Jets fans went wild, then Zach Wilson connected with Randall Cobb on a 2-point conversion.

The Eagles (5-1) got one more chance to win when they got the ball back, but the Jets’ defense stiffened – as it had all game. Hurts’ deep throw to DeVonta Smith on fourth down was knocked away, and Wilson and the offense were able to kneel down twice to seal an unlikely victory.

Hurts finished 28 of 45 for 280 yards and one touchdown but had three picks against a Jets defense that was missing starting cornerbacks Sauce Gardner and D.J. Reed.

Wilson was 19 of 33 for 186 yards and no touchdowns, but also had no turnovers.

BILLS 14, GIANTS 9: Josh Allen patiently oversaw two lengthy second-half scoring drives, capped by a 15-yard touchdown pass to Quinton Morris with 3:58 remaining, and host Buffalo (4-2) defeated undermanned but gritty New York (1-5).

What was anticipated to be a Bills blowout turned into a ground-it-out, yard-by-yard, chippy and occasionally sloppy thriller that wasn’t decided until the final play, and on an untimed down.

Giants quarterback Tyrod Taylor’s pass into the end zone glanced off Darren Waller’s finger tips facing first-and-goal from the 1. New York got an extra chance after linebacker Terrel Bernard was flagged for defensive interference on a pass intended for Waller as time expired on third-and-5 from Buffalo’s 10.

DOLPHINS 42, PANTHERS 21: Tua Tagovailoa threw three touchdown passes to three different receivers as Miami (5-1) overcame a 14-0 deficit at home to beat Carolina (0-6).

Tagovailoa was 21 of 31 for 262 yards and has an NFL-leading 1,876 yards passing this season. Miami’s Tyreek Hill caught six passes for 163 yards to bring his NFL-leading season total to 814 yards receiving.

BENGALS 17, SEAHAWKS 13: Joe Burrow threw two early touchdown passes and Cincinnati intercepted Geno Smith twice in the second half and the Bengals (3-3) held off visiting Seattle (3-2) late for their second win a row.

The Bengals defense stopped Seattle in the red zone twice late to seal the win, the last time when Smith was hit by B.J. Hill and threw incomplete on fourth-and-8 on the Bengals 9 in the final minute. Burrow was 24 for 35 for 185 yards.

RAVENS 24, TITANS 16: Lamar Jackson threw a touchdown pass and Justin Tucker kicked six field goals to lead Baltimore (4-2) past Tennessee (2-4) in London.

Jackson completed 21 of 30 passes for 223 yards and led the Ravens with 62 yards rushing, but Tucker stole the spotlight by going 6-for-6 with the longest just 41 yards.

Tennessee quarterback Ryan Tannehill limped off after the third quarter after a hit from Justin Madubuike, and was replaced by Malik Willis.

TEXANS 20, SAINTS 13: Rookie C.J. Stroud threw for 199 yards and two touchdowns and Houston (3-3) got two defensive stops late to hold on for a victory over visiting New Orleans (3-3).

The victory matches Houston’s win total from last season when the team finished 3-13-1.

Saints quarterback Derek Carr threw for a season-high 353 yards and a touchdown but often couldn’t finish drives as the Saints, lost for the third time in four games.

JAGUARS 37, COLTS 20: Trevor Lawrence threw two touchdown passes, Travis Etienne ran for a pair of scores and host Jacksonville (4-2) beat Indianapolis (3-3) for its third straight win.

Colts quarterback Gardner Minshew, getting the start in place of injured rookie Anthony Richardson, turned the ball over four times in his return to Jacksonville, which drafted him in 2019.

LIONS 20, BUCCANEERS 6: Jared Goff threw for 353 yards and two touchdowns and NFC North-leading Detroit (5-1) beat Tampa Bay (3-2) in Florida.

The streaking Lions won their fourth straight game are off to a 5-1 start for the first time since 2011.

The Lions’ defense did its part by intercepting Baker Mayfield once, limiting the Bucs to 251 yards of total offense and forcing Tampa Bay to settle for field goals of 33 and 36 yards on its only possessions that ended in Detroit’s red zone.

VIKINGS 19, BEARS 13: Kirk Cousins threw for a touchdown, Jordan Hicks returned a fumble 42 yards for a score and Minnesota (2-4) knocked Justin Fields out of the game in a victory at Chicago (1-5).

Fields was sacked four times and exited with a right hand injury early in the third quarter. Rookie Tyson Bagent came in and got strip-sacked by safety Josh Metellus on Chicago’s next drive. Hicks scooped up the loose ball near the left sideline and returned it for a touchdown, making it 19-6.

COMMANDERS 24, FALCONS 16: Sam Howell threw three short passes for touchdowns, Washington intercepted Desmond Ridder three times and the Commanders (3-3) snapped a three-game losing streak with a victory at Atlanta (3-3).

Howell shook off five more sacks – he’s now been dumped 34 times this season – to complete 14 of 23 passes for 151 yards in a close-to-the-vest passing game. The Commanders also showed more balance, rushing for 72 yards after dropping back to pass on their final 55 snaps in a loss to the Chicago Bears last week.

RAMS 26, CARDINALS 9: Cooper Kupp made seven receptions for 148 yards and his first touchdown of the season, and Kyren Williams rushed for a career-high 158 yards and a TD as Los Angeles (3-3) defeated Arizona (1-5) at Inglewood, California.

Matthew Stafford passed for 226 yards for the Rams, who scored 23 unanswered points and shut out their NFC West rivals in the second half of their first home victory of the season.